Publications 

Kraft, J., Peterson, M., Cho, S. K., Wang, Z., Hui, A.,   Rakotondrafara, A., Miller, C. L., and Miller, W. A. 2019. The 3’ untranslated region of a plant viral RNA directs efficient cap-independent translation in plant and mammalian systems. Pathogens, 8(1), 28; doi:10.3390/pathogens8010028.

Miller, C. L. 2018. The TRiCky business of reovirus assembly. Nature Microbiology, 3, 400–401. doi:10.1038/s41564-018-0137-3.

Bussiere, L., Choudhury, P., Bellaire, B., and Miller, C. L.* 2017. Characterization of a Replicating Mammalian Orthoreovirus with Tetracysteine-Tagged μNS for Live-Cell Visualization of Viral Factories, Journal of Virology Oct 27;91(22). pii: e01371-17. doi: 10.1128/JVI.01371-17.

Choudhury, P., Bussiere, L., and Miller, C. L.* 2017. Mammalian orthoreovirus factories modulate stress granule protein localization by interaction with G3BP1. Journal of Virology pii: JVI.01298-17. doi: 10.1128/JVI.01298-17 PubMed PMID: 28794026.

Hernandez, L. A., Miller, C. L., and Vaughn, E. M. 2016. Particle and subunit-based hemagglutinin vaccines provide protective efficacy against H1N1 influenza in pigs. Veterinary Microbiology.

Gupta, P., Meseke, T., and Miller, C. L.* 2015 Downregulation of key regulatory proteins in androgen dependent prostate tumor cells by oncolytic reovirus. Virology, 485:153-161. PMID: 26264969.

Kappes, M. A., Miller, C. L., and Faaberg, K. S. 2015. Porcine reproductive and respiratory syndrome virus nonstructural protein 2 (nsp2) topology and selective isoform integration in artificial membranes. Virology, 481, 51–62. PMID: 25768891.

Ikoba, U., Li, H., Peng, H., Miller, C., Yu, C., Wang, Q. 2015. Nanocarriers in Therapy of Infectious and Inflammatory Diseases. Nanoscale, 25;7(10):4291-4305. PMID: 25680099.

Gupta-Saraf, P. and Miller, C. L.* 2014. HIF-1α downregulation and apoptosis in hypoxic prostate tumor cells infected with oncolytic Mammalian orthoreovirus.  Oncotarget, 5(1.2), 561-574. PMID: 24504474.

Buehler, J., Lager, K., Vincent, A., Miller, C., Thacker, E., and Jahnke, B. 2014. Issues encountered in development of enzyme-linked immunosorbent assay for use in detecting Influenza A virus subtype H5N1 exposure in swine. Journal of Veterinary Diagnostic Investigation, 26(2):277-81. PMID: 24464555.

Carroll, K., Hastings, C., and Miller, C. L.* 2014. Amino-acids 78 and 79 of mammalian orthoreovirus protein µNS are necessary for stress granule localization, core protein λ2 interaction, and de novo virus replication. Virology, 448: 133-145. PMID: 24314644.

Kappes, M., Miller, C. L., and Faaberg, K. 2013. Highly Divergent Strains of Porcine Reproductive And Respiratory Syndrome Virus Incorporate Multiple Isoforms of Nonstructural Protein 2 into Virions. Journal of Virology 87:24 13456-13465. PMID: 24089566.

Buehler, J. Navi, D., Lorusso, A., Vincent, A., Lager, K., and Miller, C.L.* 2013. Influenza A virus PB1-F2 protein expression is regulated in a strain-specific manner by sequences located downstream of the PB1-F2 initiation codon Journal of Virology, 87(19):10687-99.  PMID: 23885074.

Chen, Q., Madsen, D., Miller, C. L., and Harris, H. 2012. Vaccine Development for Protecting Swine Against Influenza Virus. Animal Health Research Reviews, 13(2); 181-195. PMID: 23253165.

Hines, N., Killian, M., Pedersen, J., Reising, M. Mosos, N., Mathieu-Benson, C., and Miller, C. L.* 2012. An rRT-PCR Assay to Detect the Matrix Gene of a Broad Range of Avian Paramyxovirus Serotype-1. Avian Diseases, 56(2):387-95. PMID: 22856199.

Hines, N., and Miller, C. L.* 2012. Avian Paramyxovirus Serotype-1: A Review of Disease Distribution, Clinical Symptoms and Laboratory Diagnostics. Veterinary Medicine International, 2012;2012:708216. PMID: 22577610.

Miller, C. L.* 2011. Stress granules and viral replication. Future Virology 6: 11, 1329-1338.

Qin, Q., Carroll, K., Hastings, C., and Miller, C. L.* 2011. Mammalian Orthoreovirus escape from host translational shutoff correlates with stress granule disruption and is independent of eIF2α phosphorylation and PKR. Journal of Virology 85:17, 8798-8810. PMID: 21715487.

Firth, A. E., B. J. Blitvich, N. M. Wills, C. L. Miller, J. F. Atkins. 2010. Evidence for ribosomal frameshifting and a novel overlapping gene in the genomes of insect specific flaviviruses. Virology 30;399(1):153-66. PMID: 20097399.

Li, G, Y. Feng,, S. Kariyawasam, K. A. Tivendale, Y. Wannemuehler, F. Zhou, C. L. Miller, C. M. Logue, and L. K. Nolan. 2010. AatA is a novel autotransporter and virulence factor of avian pathogenic Escherichia coli. Infection and Immunity, 78.3: 898-906.

Miller, C.L*., Arnold, M.M., Broering, T. J., Hastings, C. E., and Nibert, M. L. 2010. Localization of mammalian orthoreovirus proteins to cytoplasmic factory-like structures via nonoverlapping regions of μNS. Journal of Virology. 84:2, 867-882. Co-corresponding author.

Qin, Q., Hastings, C. E. and Miller, C. L.* 2009. Mammalian orthoreovirus particles induce and are recruited into stress granules at early times post infection Journal of Virology 83:21, 11090-11101.

Miller, C.L.*, Arnold, M. M., Broering, T. J., Eichwald, C., Kim, J., Dinoso, J. B., and Nibert, M. L. 2007. Virus-derived platforms for visualizing protein associations inside cells. Molecular and Cellular Proteomics 6 (6); 1027-1038. Co-corresponding author, Cover Illustration

Abstracts

Bussiere, L. D., Gupta-Saraf, P., and Miller, C. L. 2019. Defining the mechanisms of oncolytic mammalian orthoreovirus inhibition of HIF-1α accumulation. International Oncolytic Virus Conference, Rochester, MN, Oct. 11. Poster Presentation

Bhandari, M., Guo, B., Hoang, H., Subedi, G., Barb, A., Dobbs, D., Miller, C., and Yoon, K. J. 2019. Identification and characterization of the putative PEDV receptor-binding domain. Conference of Research Workers of Animal Disease, Chicago, IL, Nov. 2-5. Oral Presentation.

Jandick, N. A., Kirner, N. S., and Miller, C. L. 2019. Analyzing genetic subtypes of breast cancer receptive to treatment with mammalian orthoreovirus. 38th Annual American Society for Virology meeting, Minneapolis, MN Jul. 20-24. Oral Presentation.

Dhar, D., Guo, B., and Miller, C.L. 2019. Mapping minimal sequence requirements for mammalian orthoreovirus genome assortment and replication. 38th Annual American Society for Virology meeting, Minneapolis, MN, July 20-24. Oral Presentation.

Jandick, N. A., Kirner, N. S., and Miller, C. L. 2019. Mammalian orthoreovirus as an oncolytic therapy and vaccine candidate for HER2 positive breast cancer. Holden Comprehensive Cancer Center Retreat, Coralville, IA, Jun 19. Oral Presentation.

Bussiere, L. D., Gupta-Saraf, P., Meseke, T., and Miller, C. L. 2018. Oncolytic mammalian orthoreovirus proteins μ1 and μ2 independently inhibit HIF-1α accumulation in hypoxic cells. International Oncolytic Virus Conference, Oxford, United Kingdom, April 9-12th. Poster Presentation.

Bussiere, L. D., Choudhury, P., Bellaire, B., Miller, C.L. 2017. Recovery of Recombinant Mammalian Orthoreovirus Expressing Fluorescent Competent Non-Structural Protein μNS for Visualization of Reovirus Factory Dynamics. American Society for Virology Meeting June 24-28, Madison, WI. Oral Presentation.

Choudhury, P., Miller, C.L. 2017.  Stress Granule Modulation by Mammalian Orthoreovirus Proteins σNS and μNS. American Society for Virology Meeting June  24-28, Madison, WI. Oral Presentation.

Choudhury, P., and Miller, C. L. 2016. Investigation into a Role for G3BP1 in Mammalian Orthoreovirus Stress Granule Modulation. American Society for Microbiology, North Central Branch 76th Annual Meeting, Oct. 21-22, Ames, Iowa. Oral Presentation.

Bussiere, L., Gupta-Saraf, P., Meseke, T., and Miller, C. L. 2016. Investigation into the modulation of the hypoxic response in prostate cancer by mammalian orthoreovirus μ1 and μ2 proteins. American Society for Microbiology, North Central Branch 76th Annual Meeting, Oct. 21-22, Ames, Iowa. Oral Presentation.

Bussiere, L., Gupta-Saraf, P., Meseke, T., and Miller, C. L. 2016. Investigation into the role of Mammalian Orthoreovirus proteins in modulation of the hypoxic response in prostate cancer. American Society for Virology Meeting, June 18-22, Blacksburg, VA. Oral Presentation.

Choudhury, P., and Miller, C. L. 2016. Investigation into a Role for G3BP/Caprin-1 in Mammalian Orthoreovirus Stress Granule Modulation. American Society for Virology Meeting, June 18-22, Blacksburg VA. Oral Presentation.

Hoang H, Madson D, Derscheid R, Miller C, Groeltz-Thrush J, Sun D, and Yoon K-J.  2016.  Development of murine monoclonal antibodies for porcine rotavirus group B and C and use in immunoassays. Proceedings, International Pig Veterinary Society Congress, Abstract # PO-PF3-161.

Choudhury, P., Guo, B., Lager, K., Cho, M., and Miller, C., 2015. Strategies for high-level antigen expression from a Mammalian Orthoreovirus vector. Vaccines Against Antigenically Variant Viruses Symposium, Nov. 5-8, Ames, IA. Poster presentation. Best Poster Award (1 of 6).

Carroll, K., and Miller, C. L. 2013. Investigation of mammalian orthoreovirus escap from host translational shutoff. The 32nd American Society for Virology Meeting, July 20-24, University Park, PA. Oral presentation.

Gupta, P., and Miller, C. L. 2013. Mammalian Orthoreovirus infection of hypoxic prostate tumor cells induces downregulation of HIF-1α and apoptotic tumor cell death. 7th Int’l Meeting on Replicating Oncolytic Virus Therapeutics. June 15-18, Quebec City, Quebec, Canada. Oral and poster presentations.

Gupta, P., Darling, R., and Miller, C. 2012. Mammalian orthoreovirus induces apoptosis in hypoxic prostate tumor cells and downregulates HIF-1α via RACK1-mediated proteasomal degradation and translational inhibition. Twelfth Annual Symposium in Virology, Oct. 5, 2012, Lincoln, NE. Poster presentation

Carroll, K., and Miller, C. 2012. Investigation of the role of mammalian orthoreovirus protein μNS in stress granule modulation. The 31st American Society for Virology Meeting, July 21-25, Madison, WI. Oral presentation.

Gupta, P., Darling, R., and Miller, C. 2012. Mammalian orthoreovirus induces apoptosis in hypoxic prostate tumor cells and downregulates HIF-1α via RACK1-mediated proteasomal degradation and translational inhibition. The 31st American Society for Virology Meeting, July 21-25, Madison, WI. Oral presentation.

Buehler, J., Navi, D., Vincent, A., Lorusso, A., Lager, K., and Miller, C. 2012. Elucidating the role of virus lineage and RNA sequence in translational regulation of influenza virus PB1-F2. The 31st American Society for Virology Meeting, July 21-25, Madison, WI. Poster presentation.

Gupta, P., and Miller, C. L. 2012. Mammalian Orthoreovirus downregulates HIF-1α in hypoxic prostate tumor cells via RACK1-mediated proteasomal degradation and translational inhibition. 2012 American Association for Cancer Research Annual Meeting. Mar 31-Apr 4, Chicago, IL. Poster Presentation. Selected as a Late Breaking Abstract.

Gupta, P. and Miller, C. L. 2011. Investigation of the impact of mammalian orthoreovirus infection on hypoxic cancer cells. The 11th Annual Symposium in Virology, University of Nebraska-Lincoln, Lincoln, NE. Poster Presentation.

Buehler, J. McCullough, D., Kohns, C., Loving, C., Lorusso, A., Vincent, A., Lager, K., and Miller, C. 2011. Characterization of swine influenza virus PB1-F2 properties in swine and human cells. The 11th Annual Symposium in Virology, University of Nebraska-Lincoln, Lincoln, NE. Poster Presentation.

Baoqing, G., Hamelin, L., and Miller, C. L. 2011. Development of a Universal Oral Mammalian Orthoreovirus Vectored Vaccine for Infectious Diseases in Animals. 71st Annual North Central Branch of the American Society for Microbiology Meeting, Oct. 7-8, Des Moines, IA. Poster Presentation.

Gupta, P. and Miller, C. L. 2011. Investigation of the impact of mammalian orthoreovirus infection on hypoxic cancer cells. 71st Annual North Central Branch of the American Society for Microbiology Meeting, Oct. 7-8, Des Moines, IA. Oral Presentation.

Buehler, J. McCullough, D., Kohns, C., Loving, C., Lorusso, A., Vincent, A., Lager, K., and Miller, C. 2011. Characterization of swine influenza virus PB1-F2 properties in swine and human cells. 71st Annual North Central Branch of the American Society for Microbiology Meeting, Oct. 7-8, Des Moines, IA. Oral Presentation.

Hamelin, L. Baoqing, G., and Miller, C. L. 2011. Development of a Universal Oral Mammalian Orthoreovirus Vectored Vaccine for Infectious Diseases in Animals. 11th Annual Merial-NIH National Veterinary Scholars Symposium. Orlando, Fl. August 4-6. Poster Presentation.

Gupta, P. and Miller, C. L. 2011. Investigation of the impact of mammalian orthoreovirus infection on hypoxic cancer cells. The 30th American Society for Virology Meeting, July 16-20, Minneapolis, MN. Oral Presentation.

Buehler, J. McCullough, D., Kohns, C., Loving, C., Lorusso, A., Vincent, A., Lager, K., and Miller, C. 2011. Characterization of swine influenza virus PB1-F2 properties in swine and human cells. The 30th American Society for Virology Meeting, July 16-20, Minneapolis, MN. Oral Presentation.

Blitvich BJ, Firth AE, Wills NM, Miller CL, Brault AC, Atkins JF. Evidence for -1 ribosomal frameshifting and a novel overlapping gene in the genomes of insect-specific flaviviruses. November 2010. The 59th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Atlanta, GA. Oral Presentation

Qin, Q., Hastings, C., and Miller, C. 2010. Disruption of Stress Granules is Important for Mammalian Orthoreovirus Escape from Host Translational Shutoff. RNA in Motion Symposium, Sept. 9-12, Ames, IA. Poster presentation.

Miller, A. G., Gupta, P., and Miller, C. 2010. Investigation of the impact of mammalianorthoreovirus infection on hypoxic tumor cells. 10th Annual Merial-NIH National Veterinary Scholars Symposium. Athens, GA, August 5-8. Poster Presentation. Poster Award, 1 of 6 from 87 posters.

Cutler TD, Hoff SJ, Wang C, Warren KJ, Zhou F, Qin Q, Miller C, Ridpath JF, Yoon K-J, Zimmerman J.  September 2010.  Inactivación de agents patógenos virales seleccionados mediante luz ultravioleta (UV254).  XXII Congreso Panamericano de Ciencias Veterinarias.  Lima, Peru.

Qin Q., Gupta, P, Hastings, C., and Miller, C. L. 2010. Mammalian orthoreovirus translation is refractory to phosphorylation of eIF2α caused by oxidative stress or hypoxia. American Society for Virology 29th Annual Meeting, Montana State University, Bozeman, MT, July 17-21. Oral Presentation.

Buehler, J., McCullough, D., Loving, C., Vincent, A., Lager, K., and Miller, C. 2010. Investigation of the function of the influenza A virus PB1-F2 protein during infection of swine and human cells with a predominant circulating strain. American Society for Virology 29th Annual Meeting, Montana State University, Bozeman, MT, July 17-21 Poster Presentation.

Qin, Q., Hastings, C., and Miller, C. 2010. Disruption of Stress Granules is Important for Mammalian Orthoreovirus Escape from Host Translational Shutoff. Keystone Symposium on Cell Biology of Virus Entry, Replication, and Pathogenesis. Feb. 17-21, Taos, NM. Poster presentation

Cutler T, Hoff S, Wang C, Warren K, Zhou F, Qin Q, Miller C, Ridpath J, Yoon K-J, Zimmerman J.  October 2009.  UV254 Inactivation of Selected Viral Pathogens.  52nd Annual Conference, American Association of Veterinary Laboratory Diagnosticians.  San Diego, California, p. 124. Oral presentation.

Cutler TD, Hoff SJ, Wang C, Warren KJ, Zhou F, Qin Q, Miller C, Ridpath JF, Yoon K-J, Zimmerman J.  December 2009.  UV254 inactivation of selected viral pathogens.   Proc 2009 International PRRS Symposium.  Chicago, Illinois, p 66. Poster presentation.

Buehler, J., E. Thacker, K. Lager, C. Miller, and B. Janke. Serologic detection of H5 influenza virus infection in swine using ELISA techniques. 2009. The 5th International Veterinary Vaccines and Diagnostics Conference, July 19-23, Madison, WI. Oral and Poster presentation.

Nibert, M. L., M. M. Arnold, T. J. Broering, and C. L. Miller. 2008. The reovirus platform: nonstructural protein μNS and its multiple roles in viral factories. 9th Annual Symposium on Antiviral Drug Resistance Targets and Mechanisms. November 16-19, 2008. Wyndham Virginia Crossings, Richmond, Virginia. Oral presentation.

Q. Qin, C. Hastings, and C. L. Miller. 2008. Mammalian orthoreovirus infection interferes with stress granule formation. American Society of Virology 27th Annual Meeting, July12-16, Ithaca, New York. Poster presentation.